Therefore, you should not be taki … ng large amounts of aspirin while using etodolac. The first of these that is used is the procedure of weighing by difference. When we tested the pure aspirin the solution turned yellow. Clean the reaction beaker to remove Acetic Acid from it, and then return the Aspirin crystals from the filter crucible to beaker. Use the molar mass of salicylic acid to find the grams needed. These independent variables are the amounts of Salicylic acid, Acetic Anhydride, water and any other substances used in the experiment, the temperature of the water used in the experiment, the time spent performing certain tasks, and any other variable that is controlled by the user.
Theoretical yield is always more than the actual yield, since we assume ideal conditions. When FeCl3 was placed into the crude aspirin the solution turned yellow with spots of purple. The salicylic acid and the acetic anhydride were mixed in a flask. What is the theoretical yield of salicylic acid for his experiment? Whenever two or more reactants are brought together to do something, they react in particular whole-number ratios. Knew because the compound did not dissolve in water.
This is done by weighing out a carefully measured amount of product and fully dissolving it in a certain amount of water. This is the most important goal of the lab. After adding the acetic acid anhydride and the sulfuric acid into the flask, the. By comparing the actual yield of the reaction and the theoretical yield, one can then find the yield percentage of the experiment. This curve, whether the liquid in the middle is higher or lower than the outside, is called the meniscus. Dependent variables: Theoretical and actual yield of aspirin.
In this experiment, a very but not perfectly pure sample of Acetylsalicylic Acid should be formed. Once again, the electrophilic oxygen takes the lone pairs between the O-H bonds to form the final product of Aspirin and acetic acid. This initial crystallization can be induced by scratching the side of the beaker: such scratching will dislodge tiny glass particles that can be used as templates to start the crystallization process. Testing showed that such extract would contain 1. To do this, place an arbitrary amount of the substance to be weighed greater than the desired amount on the Fischer balance and press the tare bar to reset the balance to zero. How many grams of water will be produced.
The goal of this lab is to synthesize a sample of acetylsalicylic acid, otherwise known as aspirin. Sodium and water react according to the following equation. It was not until 70 years after the three-fold effect of aspirin was discovered that British pharmacologist John Vane unravelled the mechanism which produces the effect. Bob222, Yesterday I posted a question and you answered me with how to calculate it. Fill a cuvette with distilled water to act as a calibration constant, and then rinse another cuvette with the solution 3 times before filling it with the Aspirin solution.
Given a more dangerous setting, misreading or disregarding directions could result in injury, or worse. The drug works by inhibiting the production of prostaglandins, body chemicals that are necessary for blood clotting and which also sen … sitize nerve endings to pain. If taken too often or in doses exceeding 4000 mg, acetaminophen can and usually will cause severe liver toxicity. In order to get a correct reading while looking at a graduated cylinder, one must look at the middle of the meniscus. Lab Report Introduction This lab has the following two concepts: synthesis of acetylsalicylic acid and analysis of acetylsalicylic acid.
With specialized tools, it is probable that efficiencies of 90% or more are possible in large-scale, commercial applications of the synthesis of Aspirin. Hypothesis: I hypothesize that salicylic acid will react with acetic anhydride to produce acetylsalicylic acid aspirin and acetic acid vinegar. Using the of aspirin, you get the number of moles of aspirin produced. The process of synthesizing aspirin is an esterification reaction, meaning that the phenol group of the salicylic acid reacts with an acid anhydride, the functional group of acetic anhydride, to make ester. Since aspirin is an acid, 5% aqueous sodium bicarbonate was used.
Since salicylic acid is being reacted with excess acetic anhydride, salicylic acid is the limiting reactant of the reaction. It is possible to repeat this process in order to end up with the desired amount of substance in the end. What is the percentage yield for the reaction shown below? Aspirin, the most widely used drug in the world, has an interesting history. Bring a 10 mL graduated cylinder to get acetic anhydride 4. Etodolac is a pain medication in the same family as ibuprofen Advil. As such, any reactant that exists in an amount more than this whole number ratio is known as an excess reactant and some will be left over when the reaction is completely finished.
Hydrochloric acid, 12 M —Ms. Aspirin has a very interesting history. Boil water on the hot plate and dissolve aspirin using a minimum amount of boiling solvent until all of the aspirin is completely dissolved homogeneous solution. Record this number on your data sheet. One of the more obvious things seen is the inefficiency of small-scale synthesis reactions. Using a periodic table, calculate the molecular weight of aspirin to 2 decimal places. Crystals appeared shiny, clear, and needle-like 11.
This indicated that our aspirin was pure and did not contain any phenol groups. Observed that crystals were clear and spiky 10. We use it for migraine, prevention of heart attacks, diabetes, and to reduce. This is known as the theoretical yield. Summary Much was learned in this experiment. While calculating it in chemistry, first thing that needs to be done is, balancing the reaction. After doing this, heat the beaker gently until it begins to boil, at which point remove it and allow it to sit for three minutes.